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The use of only a few high doses is based on the assumption that all dose-response relationships are monotonic and therefore that it is appropriate to apply a log-linear extrapolation from high-dose testing to estimate a safe reference dose ().

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The body does not make less heat in hot weather (body heat production is regulated by thyroid hormone, which is produced by the body at a constant rate) but actually makes more, due to energy-consuming processes such as perspiration.

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The radioactive iodine gradually destroys the cells that make up the thyroid gland but does not affect other body tissues.

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In both of these cases, the result is a life-long reliance on synthroid (levothyroxine) as a thyroid replacement therapy.

Methimazole is more potent than propylthiouracil and has a longer duration of action.

However, the causal relationship between the therapy and the skin defect is controversial, and anomalies related to methimazole have low birth prevalence.

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In patients with hyperthyroidism, the pattern of uptake (eg, diffuse vs nodular) varies with the underlying disorder.

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This disorder occurs in almost 1 percent of all Americans and affects women 5 to 10 times more often than men.

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The combined effect of excess free thyroid hormone along with increased catecholamine receptors causes an exaggerated response to illness, infection or surgical stress that precipitates the acute symptoms seen in thyroid storm.

Improvement in liver abnormalities after cessation of treatment.

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Theophylline clearance may decrease when hyperthyroid patients on a stable theophylline regimen become euthyroid; a reduced dose of theophylline may be needed.

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In rare circumstances, a low TSH indicates primary failure of the pituitary, or temporary inhibition of the pituitary due to another illness () and so checking the T 4 and T 3 is still clinically useful.

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Blood work is monitored following treatment to ensure return to normal thyroid status.

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RAI and continuing on methimazole.

For others, the damage is too severe, and they will need to continue taking thyroid hormone for the rest of their lives.

When initiating hyperthyroid treatment, propylthiouracil should be reserved for patients who cannot tolerate methimazole or for patients for whom radioactive iodine therapy or surgery is not appropriate treatment.

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The Endocrine Society issued a position statement on EDCs () and urged the risk assessment community to use the expertise of their members to develop new approaches to chemical risk assessments for EDCs based on principles of endocrinology.

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First of all where are you at with the Free T3 and the Free T4?

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The following two examples show the process of examining the EBGM values associated with hepatotoxicity in children and adolescents treated with either propylthiouracil or methimazole.

From the pituitary's secretion to stimulate the thyroid, this is a negative feedback system because low TSH makes the thyroid create more T4 (hyper), high TSH makes the thyroid create less T4 (hypo).

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Thyroid glands were collected from cats with normal TSH, low TSH, healthy young cats and cats with confirmed hyperthyroidism.

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